The inositol 1,4,5-trisphosphate receptor of cerebellum. Mn2+ permeability and regulation by cytosolic Mn2+.
نویسندگان
چکیده
منابع مشابه
The inositol 1,4,5-trisphosphate receptor of cerebellum. Mn2+ permeability and regulation by cytosolic Mn2+
The inositol 1,4,5-trisphosphate receptor (InsP3R), an intracellular calcium release channel, is found in virtually all cells and is abundant in the cerebellum. We used Mn2+ as a tool to study two aspects of the cerebellar InsP3R. First, to investigate the structure of the ion pore, Mn2+ permeation through the channel was determined. We found that Mn2+ can pass through the InsP3R; the selectivi...
متن کاملThe Inositol 1,4,5-Trisphosphate Receptor of Cerebellum
A B S T RA C X The inositol 1,4,5-trisphosphate receptor (InsPaR), an intracellular calcium release channel, is found in virtually all cells and is abundant in the cerebellum. We used Mn 2+ as a tool to study two aspects of the cerebellar InsP3R. First, to investigate the structure of the ion pore, Mn 2+ permeation through the channel was determined. We found that Mn 2+ can pass through the Ins...
متن کاملThe Inositol 1,4,5-Trisphosphate Receptor of Cerebellum
A B S T RA C X The inositol 1,4,5-trisphosphate receptor (InsPaR), an intracellular calcium release channel, is found in virtually all cells and is abundant in the cerebellum. We used Mn 2+ as a tool to study two aspects of the cerebellar InsP3R. First, to investigate the structure of the ion pore, Mn 2+ permeation through the channel was determined. We found that Mn 2+ can pass through the Ins...
متن کاملThe Inositol 1,4,5-Trisphosphate Receptor of Cerebellum
A B S T RA C X The inositol 1,4,5-trisphosphate receptor (InsPaR), an intracellular calcium release channel, is found in virtually all cells and is abundant in the cerebellum. We used Mn 2+ as a tool to study two aspects of the cerebellar InsP3R. First, to investigate the structure of the ion pore, Mn 2+ permeation through the channel was determined. We found that Mn 2+ can pass through the Ins...
متن کاملLateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+
Ryanodine and inositol 1,4,5-trisphosphate (IP(3)) receptors - two related families of Ca(2+) channels responsible for release of Ca(2+) from intracellular stores [1] - are biphasically regulated by cytosolic Ca(2+) [2] [3] [4]. It is thought that the resulting positive feedback allows localised Ca(2+)-release events to propagate regeneratively, and that the negative feedback limits the amplitu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1996
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.108.2.115